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A review published in 2022 in the journal NanoImpact evaluated the latest research related to genotoxic effects of titanium dioxide through in vivo studies and in vitro cell tests. Researchers summarized the results by stating TiO2 nanoparticles “could induce genotoxicity prior to cytotoxicity,” and “are likely to be genotoxic to humans.”

As a result, tariffs for titanium products are remaining similar to the ones in 2016, which will not cause bigger price fluctuations and keep a stable market.

Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods our scientists could not rule out a concern for genotoxicity and consequently they could not establish a safe level for daily intake of TiO₂ as a food additive.

What Is Titanium Dioxide?
Titanium dioxide, also called titania, is an odorless white powder and naturally occurring mineral that is widely used as a pigment for its brightness and whitening effects on a variety of materials, such as paint, plastic, paper, cosmetics, sunscreens, toothpastes and foods.
It’s produced through the sulfate or chloride process, which both involve treating titanium ore with sulfuric or hydrochloric acid to produce titanium sulfate or titanium chloride. These materials are then further processed to remove impurities and produce titanium dioxide in its final form.
Food-grade titanium dioxide differs from what’s added to plastics and paints to enhance whiteness. However, there have been concerns about the environmental impact of titanium dioxide production and the potential health risks from exposure to its particles.
Although food-grade titanium dioxide must be 99 percent pure, there’s still a risk of it containing potential contaminants, such as mercury, lead and arsenic. Additionally, inhaling the mineral over time can possibly cause it to build up in your body, leading to adverse effects.
Uses

It turns into light gray after being exposed to ultraviolet rays in sunlight for 6 to 7 hours, but it will return to its original color when placed in a dark place. It is easy to oxidize in the air and then agglomerate and deteriorate when exposed to moisture.

Titanium dioxide is considered safe for use in cosmetics products by expert bodies around the world, including Europe's Scientific Committee on Consumer Safety (SCCS) and the U.S. Food and Drug Administration (FDA). Nano grade titanium dioxide has been assessed by the SCCS and is approved by the European Commission for use as a UV filter.